All symptoms of cardiovascular disease were documented during the examination.Ī standard 12-lead ECG was recorded with the subject at rest using a paper speed of 50 mm/s (standard paper speed in Finland) and a calibration of 1 mV per 10 mm. A specially trained nurse then checked the questionnaire to make sure all the questions were answered appropriately. The subjects also completed a questionnaire regarding their health habits, medication, and known diseases or illnesses. 9 Briefly, in addition to having a standard 12-lead ECG taken, blood pressure, body mass index, and serum cholesterol were measured. Thus, our final study group included 10 899 subjects (52% of whom were men mean age 44.0☘.5 years) from the original cohort.Ī detailed account of the study rationale and procedures performed at the baseline examination has been provided previously. The study cohort comprises a total of 10 957 subjects between the ages of 30 and 59 years, but we excluded 58 ECGs that had missing data or were otherwise unreadable. The CHD Study was part of a large, prospective Mobile Clinic Health Survey, which was conducted in 35 populations from different geographic areas of Finland representative of the middle-aged Finnish population. The study population consists of subjects in the Finnish Social Insurance Institution's Coronary Heart Disease Study (CHD Study) who had undergone clinical baseline examinations between 19. Left bundle-branch block also weakly predicted arrhythmic death ( P=0.04), but right bundle-branch block was not associated with increased mortality. Subjects with intraventricular conduction delay had increased all-cause mortality (RR 2.01 CI 1.52–2.66 P<0.001), increased cardiac mortality (RR 2.53 CI 1.64–3.90 P<0.001), and an elevated risk of arrhythmic death (RR 3.11 CI 1.74–5.54 P=0.001). Prolonged QRS duration predicted all-cause mortality (multivariate-adjusted relative risk 1.48 95% confidence interval 1.22–1.81 P<0.001), cardiac mortality (RR 1.94 CI 1.44–2.63 P<0.001), and sudden arrhythmic death (RR 2.14 CI 1.38–3.33 P=0.002). QRS duration ≥110 ms was present in 1.3% (n=147) and intraventricular conduction delay in 0.6% (n=67) of the subjects. Prolonged QRS duration was defined as QRS ≥110 ms and intraventricular conduction delay as QRS ≥110 ms, without the criteria of complete or incomplete bundle-branch block. Primary end points were all-cause mortality, cardiac mortality, and arrhythmic death. We evaluated the 12-lead ECGs of 10 899 Finnish middle-aged subjects from the general population (52% of whom were men mean age 44☘.5 years) between 19 and followed them for 30☑1 years.
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About Circ: Arrhythmia and Electrophysiology.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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